Protein Details: voltage-gated potassium channel AKT6

Protein ID

ICDB_Pro_1243

Protein Name

voltage-gated potassium channel AKT6

Gene Name

AKT6; SPIK; At2g25600; F3N11.5

Organism

Arabidopsis thaliana (Mouse-ear cress)

Length

888 amino acids

AlphaFoldDB

AF-Q8GXE6-F1-model_v4.pdb

Function

Highly selective inward-rectifying potassium channel that could mediate potassium uptake in the pollen membrane. Plays an important role in pollen tube development. Assuming opened or closed conformations in response to the voltage difference across the membrane; the channel is activated by hyperpolarization. May interact with the cytoskeleton or with regulatory proteins

Sequence

MEKKKVWFWGVKDDGEGGGGRGGGRTKDAEDDVADHLSRDGTMSQYSLSKGLLPSLGANNRSSRDVILPRFIVSPFDPRYRAWETFLVFLVLYTAWASPFEFGFLQKPRPPLSILDNIVNGFFAVDIVLTFFVAFLDKVTYLLVDDPKRIAWRYASTWLIFDVVSTFPYEIFGSLLHESIQGYGIFSMLRLWRLRRVSNCFARLEKDRKYSYFWVRCSKLLLVTLFVIHCGACFLYSIAAHYPDPSKTFMALTDENWKESPIAVRYNTAMYWSITTFSTTGYGDIHGVNSREMTFILFYMVFNLGLSAYIIGNMTNLVVHVTGRTRKFRDTIQAASGFGQRNNLPVRLQDQMVAHLCLRYRTDSEGLQQQEIIDSLPKAIRSSISHYLFYEVVDKIYLFHGISNDLLFQLVTEMKAEYFPPKEDVILQNEAPTDFYILVTGAVDIIARVNGVEQVVSEAQRGHVFGEVGVLCYRPQLFTVRTKRLSQLLRLNRTVLLNLVQANVGDGAIIMNNLLQHLKDSEDPVMKGVLADTEHMLAQGKMDLPLSLCFAAARGDDLLLHQLLRRGSSPNEMDKDGRTALHIAASKGSHYCVVLLLEHGADPNIRDSEGNVPLWEAIIGRHREIAKLLAENGAKLSLDSVSYFSGLAVEKNCLDALKDIIKYGGDVTLPDGNGTTALHRAVSEGHLEIVKFLLDQGADLDWPDSYGWTPRGLADHQGNEEIKTLFHNHRPVEKKPKPIPGIPQSPVTGKPLMKYSSEPTMHSGELVLDGGQVVVSQKRKLNNFRNSLFGIISAANSADDGGEVPRSPAVPGGGGSMIYPERVTISSPENGETGGKVVLLPNSMEELLKIGENKMGFVPTKVLTREGAEIDDITLIRDGDFLLLSRDP

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

398..519

Disease

Location

Predominantly expressed in flowers; especially in pollen.

DOI ID

10.1101/gad.213902; 10.1038/45471; 10.1111/tpj.13415; 10.1126/science.1071006; 10.1105/tpc.12.6.837; 10.1104/pp.126.4.1646

RefSeq

NP_180131.3